Picrorhiza Kurroa Extract

Active Ingredient : Kutkin 2%, Kutkin 4% & Bitter 6%
Common Name : Picrorhiza
Chemical Constituents and Components : Main chemical constituents are glycosides picroside I, II and III, picrorhizin, kutkoside, kurrin, kuthinol, kutkiol, kutkisterol, kutkoside, androsin, apocynin, drosin and cucurbitacin.
Action :
Bitters / Kutkin: 1. It alters the structure of the outer membrane of the hepatocytes in such a way as to prevent penetration of the liver toxin into the interior of the cell. 2. It stimulates the action of nucleolar polymerase A, resulting in ribosomal protein synthesis and, thus stimulates the regenerative ability of the liver and formation of new hepatocytes. 3. It exhibits anti-inflammatory action on a variety of inflammatory models. 4. It modulates liver enzyme level. 5. It decreases level of lipid peroxidases and hydroperoxidases, free radical producing agents. 6. It shows curative activity against hepatotoxins like thioacetamide, galaclosamine and carbontetrachloride.Curing Diseases : 1. It is antibacterial and anti-inflammatory in action.
2. It is useful in curing fever and stomach disorders.
3. It shows hepatoprotective properties and protects liver against toxins.
4. It shows antioxidant activity.
5. It is used to lowers the high cholesterol level.Research Information : Ethanol extract of rhizome of Picrorhiza kurroa, at a dose of 20gm/kg body weight, accelerated the healing of stomach wall of indomethacin induced gastric ulcers patients. (Ray, Arun and et.al., Antioxidant activity of Rhizome of Picrorhiza kurroa on healing, Indian Journal of Clinical Biochemistry, 2002, 17(2) 44-51)Possible Combinations : Picrorhiza kurroa + curcuma longa + cassia fistula + psorela corylifolia + saussurea lappa + azardirachta indica + tinospora cordifolia + embelica officinalis + eclipta alba (used in dermatitis).